New PEGylation reagents from chemicell
chemicell offers new polyethylene glycol (PEG) derivates which are synthesized under pharmaceutical conditions in water without any organic solvents and without toxic agents. All PEG derivates are delivered as sterile aqueous solutions.
Application
The protection of biological macromolecules, peptides, antibodies, proteins, and oligonucleotides is of extreme importance in biological, immunological and pharmacological applications.
There is growing interest of PEG and its α- and/or ω-substituted derivates and the protection offered by the covalent attachment of PEG to target molecules. PEGylation has become the method of choice for the delivery of bio-pharmaceuticals.
Linear PEGs can offer one or two reactive groups that can bind with a functional group on the target molecule.
Advantages of PEGylation
- Increased bioavailability
- Increased blood circulation of the target biomolecule / drug
- Shielding receptor-mediated uptake by the reticuloendothelial system (RES)
- Shielding of antigenic and immunogenic epitopes
- Preventing recognition and degradation by proteolytic enzymes
- Increasing the apparent size of polypeptides, thus reducing the renal filtration and altering biodistribution
- Optimized pharmacokinetics
- Decreased immunogenicity
| Description | Structure Formula | Product Number | PEGMW (Da) | Amount | Price EURO | Price US$ |
|---|---|---|---|---|---|---|
| Polyethylene glycol di-succinic acid | ||||||
| α,ω-Di-succinic acid poly-ethylene glycol |  |
PDS6-1 PDS6-5 |
6000 | 1 g 5 g |
120 500 |
160 640 |
| PDS8-1 PDS8-5 |
8000 | 1 g 5 g |
120 500 |
160 640 |
||
| PDS20-1 PDS20-5 |
20000 | 1 g 5 g |
120 500 |
160 640 |
||
| Polyethylene glycol succinic acid | ||||||
| α-Methoxy-ω-succinic acid polyethylene glycol |  |
PMS5-1 PMS5-5 |
5000 | 1 g 5 g |
120 500 |
160 640 |
| Polyethylene glycol di-2,4-dicarboxylate | ||||||
| α,ω-Di-1-ester benzene-2,4-dicarboxylate-polyethylene glycol |  |
PDT6-1 PDT6-5 |
6000 | 1 g 5 g |
120 500 |
160 640 |
| PDT8-1 PDT8-5 |
8000 | 1 g 5 g |
120 500 |
160 640 |
||
| PDT20-1 PDT20-5 |
20000 | 1 g 5 g |
120 500 |
160 640 |
||
| Polyethylene glycol mono-2,4-dicarboxylate | ||||||
| α-Methoxy-ω-1-ester benzene-2,4-dicarboxylate-polyethylene glycol |  |
PMT5-1 PMT5-5 |
5000 | 1 g 5 g |
120 500 |
160 640 |
| Polyethylene glycol di-phosphate | ||||||
| α,ω-Di-phosphate polyethylene glycol |  |
PDP6-1 PDP6-5 |
6000 | 1 g 5 g |
120 500 |
160 640 |
| PDP8-1 PDP8-5 |
8000 | 1 g 5 g |
120 500 |
160 640 |
||
| PDP20-1 PDP20-5 |
20000 | 1 g 5 g |
120 500 |
160 640 |
||
| Polyethylene glycol phosphate | ||||||
| α-Methoxy-ω-phosphate poly-ethylene glycol |  |
PMP5-1 PMP5-5 |
5000 | 1 g 5 g |
120 500 |
160 640 |
| Polyethylene glycol di-Cibacron Blue | ||||||
| α,ω-di-Cibacron Blue polyethylene glycol |  |
PDC6-1 PDC6-5 |
6000 | 1 g 5 g |
120 500 |
160 640 |
| PDC8-1 PDC8-5 |
8000 | 1 g 5 g |
120 500 |
160 640 |
||
| PDC20-1 PDC-5 |
20000 | 1 g 5 g |
120 500 |
160 640 |
||
| Polyethylene glycol Cibacron Blue | ||||||
| α-Methoxy-ω-Cibacron Blue polyethylene glycol |  |
PDC5-1 PDC5-5 |
5000 | 1 g 5 g |
120 500 |
160 640 |
| Polyethylene glycol di-fluorescein | ||||||
| α,ω-Di-fluorescein poly-ethylene glycol |  |
PDF6-1 PDF6-5 |
6000 | 100 mg 500 mg |
110 440 |
145 580 |
| PDF8-1 PDF8-5 |
8000 | 100 mg 500 mg |
110 440 |
145 580 |
||
| PDF20-1 PDF20-5 |
20000 | 100 mg 500 mg |
110 440 |
145 580 |
||
| Polyethylene glycol fluorescein | ||||||
| α-Methoxy-ω-fluorescein polyethylene glycol |  |
PMF5-1 PMF5-5 |
5000 | 100 mg 500 mg |
110 440 |
145 580 |
