New PEGylation reagents from chemicell

chemicell offers new polyethylene glycol (PEG) derivates which are synthesized under pharmaceutical conditions in water without any organic solvents and without toxic agents. All PEG derivates are delivered as sterile aqueous solutions.

Application

The protection of biological macromolecules, peptides, antibodies, proteins, and oligonucleotides is of extreme importance in biological, immunological and pharmacological applications.

There is growing interest of PEG and its α- and/or ω-substituted derivates and the protection offered by the covalent attachment of PEG to target molecules. PEGylation has become the method of choice for the delivery of bio-pharmaceuticals.

Linear PEGs can offer one or two reactive groups that can bind with a functional group on the target molecule.

Advantages of PEGylation

Increased bioavailability
Increased blood circulation of the target biomolecule / drug
Shielding receptor-mediated uptake by the reticuloendothelial system (RES)
Shielding of antigenic and immunogenic epitopes
Preventing recognition and degradation by proteolytic enzymes
Increasing the apparent size of polypeptides, thus reducing the renal filtration and altering biodistribution
Optimized pharmacokinetics
Decreased immunogenicity

Description	Product Number	PEG_MW (Da)	Amount	Price EURO	Price US$
Polyethylene glycol di-succinic acid
α,ω-Di-succinic acid poly-ethylene glycol	PDS6-1 PDS6-5	6000	1 g 5 g	120 500	160 640
	PDS8-1 PDS8-5	8000	1 g 5 g	120 500	160 640
	PDS20-1 PDS20-5	20000	1 g 5 g	120 500	160 640
Polyethylene glycol succinic acid
α-Methoxy-ω-succinic acid polyethylene glycol	PMS5-1 PMS5-5	5000	1 g 5 g	120 500	160 640
Polyethylene glycol di-phosphate
α,ω-Di-phosphate polyethylene glycol	PDP6-1 PDP6-5	6000	1 g 5 g	120 500	160 640
	PDP8-1 PDP8-5	8000	1 g 5 g	120 500	160 640
	PDP20-1 PDP20-5	20000	1 g 5 g	120 500	160 640
Polyethylene glycol phosphate
α-Methoxy-ω-phosphate poly-ethylene glycol	PMP5-1 PMP5-5	5000	1 g 5 g	120 500	160 640
Polyethylene glycol di-Cibacron Blue
α,ω-di-Cibacron Blue polyethylene glycol	PDC6-1 PDC6-5	6000	1 g 5 g	120 500	160 640
	PDC8-1 PDC8-5	8000	1 g 5 g	120 500	160 640
	PDC20-1 PDC20-5	20000	1 g 5 g	120 500	160 640
Polyethylene glycol Cibacron Blue
α-Methoxy-ω-Cibacron Blue polyethylene glycol	PDC5-1 PDC5-5	5000	1 g 5 g	120 500	160 640
Polyethylene glycol di-fluorescein
α,ω-Di-fluorescein poly-ethylene glycol	PDF6-1 PDF6-5	6000	100 mg 500 mg	110 440	145 580
	PDF8-1 PDF8-5	8000	100 mg 500 mg	110 440	145 580
	PDF20-1 PDF20-5	20000	100 mg 500 mg	110 440	145 580
Polyethylene glycol fluorescein
α-Methoxy-ω-fluorescein polyethylene glycol	PMF5-1 PMF5-5	5000	100 mg 500 mg	110 440	145 580
Polyethylene glycol di-amine
α,ω-Di-amine polyethylene glycol	PDA6-1 PDA6-5	6000	1 g 5 g	120 500	160 640
	PDA8-1 PDA8-5	8000	1 g 5 g	120 500	160 640
	PDA20-1 PDA20-5	20000	1 g 5 g	120 500	160 640
Polyethylene glycol amine
α-Methoxy-ω-amine polyethylene glycol	PMA5-1 PMA5-5	5000	1 g 5 g	120 500	160 640
Polyethylene glycol di-Rhodamine
α,ω-Di-Rhodamine polyethylene glycol	PDR6-1 PDR6-5	6000	100 mg 500 mg	110 440	145 580
	PDR8-1 PDR8-5	8000	100 mg 500 mg	110 440	145 580
	PDR20-1 PDR20-5	20000	100 mg 500 mg	110 440	145 580
Polyethylene glycol Rhodamine
α-Methoxy-ω-Rhodamine polyethylene glycol	PMR5-1 PMR5-5	5000	100 mg 500 mg	110 440	145 580