SiMAG - Hydrazide

This procedure describes the covalent coupling of aldehyde- or ketone-group containing ligands through the formation of stable hydrazone linkages on SiMAG-Hydrazide.

Glycoproteins can be immobilized by oxidation with sodium periodate to generate formyl groups on their carbohydrate chains.

This coupling method is a powerful way to immobilize proteins and leave critical active sites free.